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Research Article
 
DOI:10.11909/j.issn.1671-5411.2019.09.008
Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation
George Bazoukis,Konstantinos P Letsas,Konstantinos Vlachos,Athanasios Saplaouras,Dimitrios Asvestas,Konstantinos Tyrovolas,Aikaterini Rokiza,Eirini Pagkalidou,Gary Tse,Stavros Stavrakis,Antonios Sideris,Michael Efremidis.Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation.J Geriatr Cardiol 2019,16(9):671~675
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Authors:George Bazoukis1;Konstantinos P Letsas1;Konstantinos Vlachos1;Athanasios Saplaouras1;Dimitrios Asvestas1;Konstantinos Tyrovolas1;Aikaterini Rokiza1;Eirini Pagkalidou2;Gary Tse3;Stavros Stavrakis4;Antonios Sideris5;Michael Efremidis5

Author Affiliation:1.Department of Cardiology, Electrophysiology Laboratory, Evangelismos General Hospital of Athens, Athens, Greece;2.Department of Hygiene and Epidemiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;3.Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, SAR, China;4.Department of Medicine, Cardiovascular Section, Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA;5.Department of Cardiology, Electrophysiology Laboratory, Evangelismos General Hospital of Athens, Athens, Greece;

Foundation:

Abstract: Background Red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) are simple hematologic indices that have been used to predict adverse outcomes in different clinical settings. The aim of our study is to determine whether RDW and NLR can predict atrial fibrillation (AF) recurrence in patients undergoing AF ablation. Methods Consecutive patients, without known hematological disorders, who underwent AF catheter ablation between January 2014 and April 2017 were enrolled into this study. Blood samples were taken one day before and five hours after the ablation procedure. Results A total of 346 patients (224 males (65%), mean age: 59 ± 11 years old) were included. After a mean follow up of 26.2 ± 12.1 months, 80 (23.1%) patients experienced late AF recurrence (defined as any recurrence after the blanking period of three months), while 97 (28%) patients experienced early AF recurrence during the blanking period. Univariate analysis showed that early arrhythmia recurrence, type of AF and NLR after the procedure were significantly associated with late AF recurrence, while early arrhythmia recurrence and NLR remained significant in multivariate analysis. RDW was not associated with late AF recurrence. None of the parameters above predicted early arrhythmia recurrence. Conclusions Simple and inexpensive hematological indices such as NLR should be evaluated for their ability to predict AF recurrence in patients undergoing catheter ablation in larger prospective studies.

Keywords:

Atrial fibrillation; Neutrophils; Radiofrequency ablation
Received:November 18, 2018        Accepted:January 30, 2019   Published Online:September 28, 2019
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